The city is mostly in Fort Bend County, with a small portion within Harris County.
The Missouri City area's recent upscale, master-planned residential developments include Lake Olympia, south of Quail Valley, and portions of Riverstone, south of State Highway 6. The nearby unincorporated area of Sienna Plantation, also located south of State Highway 6, is situated on and around land once occupied by plantations where, among other things, sugarcane and cotton were harvested.
Missouri City is served by US90A, Beltway 8 (Sam Houston Tollway), Fort Bend Toll Road, State Highway 6, FM 1092 (Murphy Road),FM 2234 (Texas Parkway), and FM 3345 (Cartwright Road). Other nearby highways are US 59, and Interstate 610 (Loop 610).
Although Missouri City does not have public transportation within the city limits itself, it is part of the service area of METRO. METRO operates the Missouri City Park and Ride located on Beltway 8 and Fondren Road, which is the terminus of express bus Route 163 Fondren to Sharpstown and Downtown Houston and Route 170 Missouri City Express to the Texas Medical Center.
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